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Innate and Adaptive Responses to Heat Shock Proteins in Behcet’s Disease
Author
Source
Genetics Research International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Behcet’s disease (BD) is a systemic, chronic inflammatory disorder with both innate and adaptive immune responses.
Heat shock proteins (HSP) are highly conserved molecules in different species with scavenger activity and involved in correct folding of newly synthesized proteins.
T and B cell responses against HSPs are observed in BD patients in both αβ and γδ T-cell populations.
60-kD HSP (HSP60) is also shown to be recognized by pattern recognition receptors such as toll-like receptors (TLR) and is suggested to be an endogenous “danger” signal to the immune system with rapid inflammatory cytokine releases and enhancement of adaptive Th1-type responses.
Elucidating the exact role of HSPs in BD pathogenesis might pave the way to less toxic therapeutic approaches to BD, such as antibacterial therapies and immunomodulation.
American Psychological Association (APA)
Direskeneli, Rafi Haner. 2013. Innate and Adaptive Responses to Heat Shock Proteins in Behcet’s Disease. Genetics Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-457273
Modern Language Association (MLA)
Direskeneli, Rafi Haner. Innate and Adaptive Responses to Heat Shock Proteins in Behcet’s Disease. Genetics Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-457273
American Medical Association (AMA)
Direskeneli, Rafi Haner. Innate and Adaptive Responses to Heat Shock Proteins in Behcet’s Disease. Genetics Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-457273
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457273