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Downstream and Intermediate Interactions of Synovial Sarcoma-Associated Fusion Oncoproteins and Their Implication for Targeted Therapy
Joint Authors
Jurkowska, Monika
Debiec-Rychter, Maria
Rutkowski, Piotr
Siedlecki, Janusz A.
Przybyl, Joanna
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-25
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Synovial sarcoma (SS), an aggressive type of soft tissue tumor, occurs mostly in adolescents and young adults.
The origin and molecular mechanism of the development of SS remain only partially known.
Over 90% of SS cases are characterized by the t(X;18)(p11.2;q11.2) translocation, which results mainly in the formation of SS18-SSX1 or SS18-SSX2 fusion genes.
In recent years, several reports describing direct and indirect interactions of SS18-SSX1/SSX2 oncoproteins have been published.
These reports suggest that the fusion proteins particularly affect the cell growth, cell proliferation, TP53 pathway, and chromatin remodeling mechanisms, contributing to SS oncogenesis.
Additional research efforts are required to fully explore the protein-protein interactions of SS18-SSX oncoproteins and the pathways that are regulated by these partnerships for the development of effective targeted therapy.
American Psychological Association (APA)
Przybyl, Joanna& Jurkowska, Monika& Rutkowski, Piotr& Debiec-Rychter, Maria& Siedlecki, Janusz A.. 2012. Downstream and Intermediate Interactions of Synovial Sarcoma-Associated Fusion Oncoproteins and Their Implication for Targeted Therapy. Sarcoma،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-457279
Modern Language Association (MLA)
Przybyl, Joanna…[et al.]. Downstream and Intermediate Interactions of Synovial Sarcoma-Associated Fusion Oncoproteins and Their Implication for Targeted Therapy. Sarcoma No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-457279
American Medical Association (AMA)
Przybyl, Joanna& Jurkowska, Monika& Rutkowski, Piotr& Debiec-Rychter, Maria& Siedlecki, Janusz A.. Downstream and Intermediate Interactions of Synovial Sarcoma-Associated Fusion Oncoproteins and Their Implication for Targeted Therapy. Sarcoma. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-457279
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457279