Structure Topology Prediction of Discriminative Sequence Motifs in Membrane Proteins with Domains of Unknown Functions

Joint Authors

Heinke, Florian
Grunert, Steffen
Labudde, Dirk

Source

Structural Biology

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-02-28

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Natural & Life Sciences (Multidisciplinary)

Abstract EN

Motivation.

Membrane proteins play essential roles in cellular processes of organisms.

Photosynthesis, transport of ions and small molecules, signal transduction, and light harvesting are examples of processes which are realised by membrane proteins and contribute to a cell's specificity and functionality.

The analysis of membrane proteins has shown to be an important part in the understanding of complex biological processes.

Genome-wide investigations of membrane proteins have revealed a large number of short, distinct sequence motifs.

Results.

The in silico analysis of 32 membrane protein families with domains of unknown functions discussed in this study led to a novel approach which describes the separation of motifs by residue-specific distributions.

Based on these distributions, the topology structure of the majority of motifs in hypothesised membrane proteins with unknown topology can be predicted.

Conclusion.

We hypothesise that short sequence motifs can be separated into structure-forming motifs on the one hand, as such motifs show high prediction accuracy in all investigated protein families.

This points to their general importance in α-helical membrane protein structure formation and interaction mediation.

On the other hand, motifs which show high prediction accuracies only in certain families can be classified as functionally important and relevant for family-specific functional characteristics.

American Psychological Association (APA)

Grunert, Steffen& Heinke, Florian& Labudde, Dirk. 2013. Structure Topology Prediction of Discriminative Sequence Motifs in Membrane Proteins with Domains of Unknown Functions. Structural Biology،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-457280

Modern Language Association (MLA)

Grunert, Steffen…[et al.]. Structure Topology Prediction of Discriminative Sequence Motifs in Membrane Proteins with Domains of Unknown Functions. Structural Biology No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-457280

American Medical Association (AMA)

Grunert, Steffen& Heinke, Florian& Labudde, Dirk. Structure Topology Prediction of Discriminative Sequence Motifs in Membrane Proteins with Domains of Unknown Functions. Structural Biology. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-457280

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-457280