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The Role of Tobacco-Derived Carcinogens in Pancreas Cancer
Joint Authors
Reeves, Helen L.
Charnley, Richard M.
Daly, Anne K.
Lochan, Rajiv
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The extremely poor outcome from pancreas cancer is well known.
However, its aetiology less well appreciated, and the molecular mechanisms underlying this are poorly understood.
Tobacco usage is one of the strongest risk factors for this disease, and this is a completely avoidable hazard.
In addition, there are well described hereditary diseases which predispose, and familial pancreas cancer.
We have sought here to summarise the role of tobacco-derived carcinogens and the mode of their tumorigenic action on the pancreas.
There is compelling evidence from animal and human studies (laboratory including cell line studies and epidemiologic) that tobacco derived carcinogens cause pancreas cancer.
However, the manner in which they do so is not entirely apparent.
There is also compelling evidence that synergism with genetic and other life-style factors—like diet obesity—results in a multifactorial causation of the disease.
Ascertaining the role of tobacco carcinogens in the development of this cancer and their interaction with other risk factors will enable novel therapeutic and preventative strategies to improve outcome from this appalling malignancy.
American Psychological Association (APA)
Lochan, Rajiv& Reeves, Helen L.& Daly, Anne K.& Charnley, Richard M.. 2011. The Role of Tobacco-Derived Carcinogens in Pancreas Cancer. ISRN Oncology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-457281
Modern Language Association (MLA)
Lochan, Rajiv…[et al.]. The Role of Tobacco-Derived Carcinogens in Pancreas Cancer. ISRN Oncology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-457281
American Medical Association (AMA)
Lochan, Rajiv& Reeves, Helen L.& Daly, Anne K.& Charnley, Richard M.. The Role of Tobacco-Derived Carcinogens in Pancreas Cancer. ISRN Oncology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-457281
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457281