Metastasis Update : Human Prostate Carcinoma Invasion via Tubulogenesis
Joint Authors
Nagle, Raymond B.
Cress, Anne E.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
This paper proposes that human prostate carcinoma primarily invades as a cohesive cell collective through a mechanism similar to embryonic tubulogenesis, instead of the popular epithelial-mesenchymal transformation (EMT) model.
Evidence supporting a tubulogenesis model is presented, along with suggestions for additional research.
Additionally, observations documenting cell adhesion molecule changes in tissue and stromal components are reviewed, allowing for comparisons between the current branching morphogenesis models and the tubulogenesis model.
Finally, the implications of this model on prevailing views of therapeutic and diagnostic strategies for aggressive prostatic disease are considered.
American Psychological Association (APA)
Nagle, Raymond B.& Cress, Anne E.. 2011. Metastasis Update : Human Prostate Carcinoma Invasion via Tubulogenesis. Prostate Cancer،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-457285
Modern Language Association (MLA)
Nagle, Raymond B.& Cress, Anne E.. Metastasis Update : Human Prostate Carcinoma Invasion via Tubulogenesis. Prostate Cancer No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-457285
American Medical Association (AMA)
Nagle, Raymond B.& Cress, Anne E.. Metastasis Update : Human Prostate Carcinoma Invasion via Tubulogenesis. Prostate Cancer. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-457285
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457285