![](/images/graphics-bg.png)
The GHIGF-I Axis and Cognitive Changes across a 4-Year Period in Healthy Adults
Joint Authors
Arwert, Lucia I.
Deijen, Jan Berend
Drent, Madeleine L.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
After the age of 40, the amount of growth hormone in humans decreases.
The reduced activity of the GH-IGF axis may play a role in age-related cognitive impairments.
In the present study, mood and cognition of 30 healthy subjects (7 males, 23 females, aged 41–76 yr, mean age 60.9±9.0) were examined twice.
At baseline, we determined fasting blood levels of GH and IGF-I.
Mood and cognitive status were assessed at baseline and after, on the average, 3 years and 9 months of followup.
Working memory performance decreased over the years in the low IGF-group (P=.007), but not the high IGF-I group.
Higher levels of GH were related with a better working memory at the second test (r=0.42, P=.01) while higher levels of IGF-I tended to be related with a better working memory (r=0.3, P=.06).
The results suggest that higher serum levels of GH and IGF-I preserve the quality of working memory functions over the years.
American Psychological Association (APA)
Deijen, Jan Berend& Arwert, Lucia I.& Drent, Madeleine L.. 2011. The GHIGF-I Axis and Cognitive Changes across a 4-Year Period in Healthy Adults. ISRN Endocrinology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-457295
Modern Language Association (MLA)
Deijen, Jan Berend…[et al.]. The GHIGF-I Axis and Cognitive Changes across a 4-Year Period in Healthy Adults. ISRN Endocrinology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-457295
American Medical Association (AMA)
Deijen, Jan Berend& Arwert, Lucia I.& Drent, Madeleine L.. The GHIGF-I Axis and Cognitive Changes across a 4-Year Period in Healthy Adults. ISRN Endocrinology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-457295
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457295