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N-Glycosylation Modification of Plant-Derived Virus-Like Particles : An Application in Vaccines
Joint Authors
Jeon, Jae-Heung
Kim, Hyun-Soon
Ko, Kisung
Lee, Kyung Jin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Plants have been developed as an alternative system to mammalian cells for production of recombinant prophylactic or therapeutic proteins for human and animal use.
Effective plant expression systems for recombinant proteins have been established with the optimal combination of gene expression regulatory elements and control of posttranslational processing of recombinant glycoproteins.
In plant, virus-like particles (VLPs), viral “empty shells” which maintain the same structural characteristics of virions but are genome-free, are considered extremely promising as vaccine platforms and therapeutic delivery systems.
Unlike microbial fermentation, plants are capable of carrying out N-glycosylation as a posttranslational modification of glycoproteins.
Recent advances in the glycoengineering in plant allow human-like glycomodification and optimization of desired glycan structures for enhancing safety and functionality of recombinant pharmaceutical glycoproteins.
In this review, the current plant-derived VLP approaches are focused, and N-glycosylation and its in planta modifications are discussed.
American Psychological Association (APA)
Kim, Hyun-Soon& Jeon, Jae-Heung& Lee, Kyung Jin& Ko, Kisung. 2014. N-Glycosylation Modification of Plant-Derived Virus-Like Particles : An Application in Vaccines. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-457309
Modern Language Association (MLA)
Kim, Hyun-Soon…[et al.]. N-Glycosylation Modification of Plant-Derived Virus-Like Particles : An Application in Vaccines. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-457309
American Medical Association (AMA)
Kim, Hyun-Soon& Jeon, Jae-Heung& Lee, Kyung Jin& Ko, Kisung. N-Glycosylation Modification of Plant-Derived Virus-Like Particles : An Application in Vaccines. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-457309
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457309