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Traditional Medicine to Modern Pharmacogenomics : Ayurveda Prakriti Type and CYP2C19 Gene Polymorphism Associated with the Metabolic Variability
Joint Authors
Ghodke, Yogita
Joshi, Kalpana
Patwardhan, Bhushan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-08
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Traditional Indian medicine—Ayurveda—classifies the human population into three major constituents or Prakriti known as Vata, Pitta and Kapha types.
Earlier, we have demonstrated a proof of concept to support genetic basis for Prakriti.
The descriptions in Ayurveda indicate that individuals with Pitta Prakriti are fast metabolizers while those of Kapha Prakriti are slow metabolizers.
We hypothesized that different Prakriti may have different drug metabolism rates associated with drug metabolizing enzyme (DME) polymorphism.
We did CYP2C19 (Phase I DME) genotyping in 132 unrelated healthy subjects of either sex by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.
We observed significant association between CYP2C19 genotype and major classes of Prakriti types.
The extensive metabolizer (EM) genotype (*1/*1, *1/*2, *1/*3) was found to be predominant in Pitta Prakriti (91%).
Genotype (*1/*3) specific for EM group was present only in Pitta Prakriti.
Poor metabolizer (PM) genotype (*2/*2, *2/*3, *3/*3) was highest (31%) in Kapha Prakriti when compared with Vata (12%) and Pitta Prakriti (9%).
Genotype (*2/*3) which is typical for PM group was significant in Kapha Prakriti (odds ratio = 3.5, P = .008).
We observed interesting correlations between CYP2C19 genotypes and Prakriti with fast and slow metabolism being one of the major distinguishing and differentiating characteristics.
These observations are likely to have significant impact on phenotype-genotype correlation, drug discovery, pharmacogenomics and personalized medicine.
American Psychological Association (APA)
Ghodke, Yogita& Joshi, Kalpana& Patwardhan, Bhushan. 2011. Traditional Medicine to Modern Pharmacogenomics : Ayurveda Prakriti Type and CYP2C19 Gene Polymorphism Associated with the Metabolic Variability. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-457311
Modern Language Association (MLA)
Ghodke, Yogita…[et al.]. Traditional Medicine to Modern Pharmacogenomics : Ayurveda Prakriti Type and CYP2C19 Gene Polymorphism Associated with the Metabolic Variability. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-457311
American Medical Association (AMA)
Ghodke, Yogita& Joshi, Kalpana& Patwardhan, Bhushan. Traditional Medicine to Modern Pharmacogenomics : Ayurveda Prakriti Type and CYP2C19 Gene Polymorphism Associated with the Metabolic Variability. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-457311
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457311