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Replication of Alphaviruses : A Review on the Entry Process of Alphaviruses into Cells
Joint Authors
Ng, Mary Mah-Lee
Leung, Jason Yat-Sing
Chu, Justin Jang Hann
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Alphaviruses are small, enveloped viruses, ~70 nm in diameter, containing a single-stranded, positive-sense, RNA genome.
Viruses belonging to this genus are predominantly arthropod-borne viruses, known to cause disease in humans.
Their potential threat to human health was most recently exemplified by the 2005 Chikungunya virus outbreak in La Reunion, highlighting the necessity to understand events in the life-cycle of these medically important human pathogens.
The replication and propagation of viruses is dependent on entry into permissive cells.
Viral entry is initiated by attachment of virions to cells, leading to internalization, and uncoating to release genetic material for replication and propagation.
Studies on alphaviruses have revealed entry via a receptor-mediated, endocytic pathway.
In this paper, the different stages of alphavirus entry are examined, with examples from Semliki Forest virus, Sindbis virus, Chikungunya virus, and Venezuelan equine encephalitis virus described.
American Psychological Association (APA)
Leung, Jason Yat-Sing& Ng, Mary Mah-Lee& Chu, Justin Jang Hann. 2011. Replication of Alphaviruses : A Review on the Entry Process of Alphaviruses into Cells. Advances in Virology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-457324
Modern Language Association (MLA)
Leung, Jason Yat-Sing…[et al.]. Replication of Alphaviruses : A Review on the Entry Process of Alphaviruses into Cells. Advances in Virology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-457324
American Medical Association (AMA)
Leung, Jason Yat-Sing& Ng, Mary Mah-Lee& Chu, Justin Jang Hann. Replication of Alphaviruses : A Review on the Entry Process of Alphaviruses into Cells. Advances in Virology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-457324
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457324