Urotensin-II : More Than a Mediator for Kidney
Joint Authors
Source
International Journal of Nephrology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Human urotensin-II (hU-II) is one of the most potent vasoconstrictors in mammals.
Although both hU-II and its receptor, GPR14, are detected in several tissues, kidney is a major source of U-II in humans.
Recent studies suggest that U-II may have a possible autocrine/paracrine functions in kidney and may be an important target molecule in studying renal pathophysiology.
It has several effects on tubular transport and probably has active role in renal hemodynamics.
Although it is an important peptide in renal physiology, certain diseases, such as hypertension and glomerulonephritis, may alter the expression of U-II.
As might be expected, oxidative stress, mediators, and inflammation are like a devil's triangle in kidney diseases, mostly they induce each other.
Since there is a complex relationship between U-II and oxidative stress, and other mediators, such as transforming growth factor β1 and angiotensin II, U-II is more than a mediator in glomerular diseases.
Although it is an ancient peptide, known for 31 years, it looks like that U-II will continue to give new messages as well as raising more questions as research on it increases.
In this paper, we mainly discuss the possible role of U-II on renal physiology and its effect on kidney diseases.
American Psychological Association (APA)
Balat, Ayşe& Büyükçelik, Mithat. 2012. Urotensin-II : More Than a Mediator for Kidney. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-457337
Modern Language Association (MLA)
Balat, Ayşe& Büyükçelik, Mithat. Urotensin-II : More Than a Mediator for Kidney. International Journal of Nephrology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-457337
American Medical Association (AMA)
Balat, Ayşe& Büyükçelik, Mithat. Urotensin-II : More Than a Mediator for Kidney. International Journal of Nephrology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-457337
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457337