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Host Defense and the Airway Epithelium : Frontline Responses That Protect against Bacterial Invasion and Pneumonia
Joint Authors
Anderson, Deborah M.
Eisele, Nicholas A.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-22
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Airway epithelial cells are the first line of defense against invading microbes, and they protect themselves through the production of carbohydrate and protein matrices concentrated with antimicrobial products.
In addition, they act as sentinels, expressing pattern recognition receptors that become activated upon sensing bacterial products and stimulate downstream recruitment and activation of immune cells which clear invading microbes.
Bacterial pathogens that successfully colonize the lungs must resist these mechanisms or inhibit their production, penetrate the epithelial barrier, and be prepared to resist a barrage of inflammation.
Despite the enormous task at hand, relatively few virulence factors coordinate the battle with the epithelium while simultaneously providing resistance to inflammatory cells and causing injury to the lung.
Here we review mechanisms whereby airway epithelial cells recognize pathogens and activate a program of antibacterial pathways to prevent colonization of the lung, along with a few examples of how bacteria disrupt these responses to cause pneumonia.
American Psychological Association (APA)
Eisele, Nicholas A.& Anderson, Deborah M.. 2011. Host Defense and the Airway Epithelium : Frontline Responses That Protect against Bacterial Invasion and Pneumonia. Journal of Pathogens،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-457338
Modern Language Association (MLA)
Eisele, Nicholas A.& Anderson, Deborah M.. Host Defense and the Airway Epithelium : Frontline Responses That Protect against Bacterial Invasion and Pneumonia. Journal of Pathogens No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-457338
American Medical Association (AMA)
Eisele, Nicholas A.& Anderson, Deborah M.. Host Defense and the Airway Epithelium : Frontline Responses That Protect against Bacterial Invasion and Pneumonia. Journal of Pathogens. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-457338
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457338