Molecular Mechanisms of Renal Cellular Nephrotoxicity due to Radiocontrast Media
Joint Authors
Navarra, Michele
Pisani, Antonio
Michael, Ashour
Riccio, Eleonora
Andreucci, Michele
Bramanti, Placido
Faga, Teresa
Sabbatini, Massimo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Modern iodinated radiocontrast media are all based on the triiodinated benzene ring with various chemical modifications having been made over the last few decades in order to reduce their toxicity.
However, CIN remains a problem especially in patients with pre-existing renal failure.
In vitro studies have demonstrated that all RCM are cytotoxic.
RCM administration in vivo may lead to a decrease in renal medullary oxygenation leading to the generation of reactive oxygen species that may cause harmful effects to renal tissue.
In addition, endothelin and adenosine release and decreased nitric oxide levels may worsen the hypoxic milieu.
In vitro cell culture studies together with sparse in vivo rat model data have shown that important cell signalling pathways are affected by RCM.
In particular, the prosurvival and proproliferative kinases Akt and ERK1/2 have been shown to be dephosphorylated (deactivated), whilst proinflammatory/cell death molecules such as the p38 and JNK kinases and the transcription factor NF-κB may be activated by RCM, accompanied by activation of apoptotic mediators such as caspases.
Increasing our knowledge of the mechanisms of RCM action may help to develop future therapies for CIN.
American Psychological Association (APA)
Michael, Ashour& Faga, Teresa& Pisani, Antonio& Riccio, Eleonora& Bramanti, Placido& Sabbatini, Massimo…[et al.]. 2014. Molecular Mechanisms of Renal Cellular Nephrotoxicity due to Radiocontrast Media. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-457340
Modern Language Association (MLA)
Michael, Ashour…[et al.]. Molecular Mechanisms of Renal Cellular Nephrotoxicity due to Radiocontrast Media. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-457340
American Medical Association (AMA)
Michael, Ashour& Faga, Teresa& Pisani, Antonio& Riccio, Eleonora& Bramanti, Placido& Sabbatini, Massimo…[et al.]. Molecular Mechanisms of Renal Cellular Nephrotoxicity due to Radiocontrast Media. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-457340
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457340