Worldwide Dissemination of the NDM-Type Carbapenemases in Gram-Negative Bacteria
Joint Authors
Poirel, Laurent
Dortet, Laurent
Nordmann, Patrice
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The emergence of one of the most recently described carbapenemases, namely, the New Delhi metallo-lactamase (NDM-1), constitutes a critical and growingly important medical issue.
This resistance trait compromises the efficacy of almost all lactams (except aztreonam), including the last resort carbapenems.
Therapeutical options may remain limited mostly to colistin, tigecycline, and fosfomycin.
The main known reservoir of NDM producers is the Indian subcontinent whereas a secondary reservoir seems to have established the Balkans regions and the Middle East.
Although the spread of blaNDM-like genes (several variants) is derived mostly by conjugative plasmids in Enterobacteriaceae, this carbapenemase has also been identified in P.
aeruginosa and Acinetobacter spp.
Acinetobacter sp.
may play a pivotal role for spreading blaNDM genes for its natural reservoir to Enterobacteriaceae.
Rapid diagnostic techniques (Carba NP test) and screening of carriers are the cornerstone to try to contain this outbreak which threatens the efficacy of the modern medicine.
American Psychological Association (APA)
Dortet, Laurent& Poirel, Laurent& Nordmann, Patrice. 2014. Worldwide Dissemination of the NDM-Type Carbapenemases in Gram-Negative Bacteria. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-457347
Modern Language Association (MLA)
Dortet, Laurent…[et al.]. Worldwide Dissemination of the NDM-Type Carbapenemases in Gram-Negative Bacteria. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-457347
American Medical Association (AMA)
Dortet, Laurent& Poirel, Laurent& Nordmann, Patrice. Worldwide Dissemination of the NDM-Type Carbapenemases in Gram-Negative Bacteria. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-457347
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457347