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Coactivators in PPAR-Regulated Gene Expression
Joint Authors
Bai, Liang
Jia, Yuzhi
Reddy, Janardan K.
Borensztajn, Jayme
Xu, Jianming
Vluggens, Aurore
Viswakarma, Navin
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-05
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Peroxisome proliferator-activated receptor (PPAR)α, β (also known as δ), and γ function as sensors for fatty acids and fatty acid derivatives and control important metabolic pathways involved in the maintenance of energy balance.
PPARs also regulate other diverse biological processes such as development, differentiation, inflammation, and neoplasia.
In the nucleus, PPARs exist as heterodimers with retinoid X receptor-α bound to DNA with corepressor molecules.
Upon ligand activation, PPARs undergo conformational changes that facilitate the dissociation of corepressor molecules and invoke a spatiotemporally orchestrated recruitment of transcription cofactors including coactivators and coactivator-associated proteins.
While a given nuclear receptor regulates the expression of a prescribed set of target genes, coactivators are likely to influence the functioning of many regulators and thus affect the transcription of many genes.
Evidence suggests that some of the coactivators such as PPAR-binding protein (PBP/PPARBP)/thyroid hormone receptor-associated protein 220 (TRAP220)/mediator complex subunit 1 (MED1) may exert a broader influence on the functions of several nuclear receptors and their target genes.
Investigations into the role of coactivators in the function of PPARs should strengthen our understanding of the complexities of metabolic diseases associated with energy metabolism.
American Psychological Association (APA)
Viswakarma, Navin& Jia, Yuzhi& Bai, Liang& Vluggens, Aurore& Borensztajn, Jayme& Xu, Jianming…[et al.]. 2010. Coactivators in PPAR-Regulated Gene Expression. PPAR Research،Vol. 2010, no. 2010, pp.1-21.
https://search.emarefa.net/detail/BIM-457354
Modern Language Association (MLA)
Viswakarma, Navin…[et al.]. Coactivators in PPAR-Regulated Gene Expression. PPAR Research No. 2010 (2010), pp.1-21.
https://search.emarefa.net/detail/BIM-457354
American Medical Association (AMA)
Viswakarma, Navin& Jia, Yuzhi& Bai, Liang& Vluggens, Aurore& Borensztajn, Jayme& Xu, Jianming…[et al.]. Coactivators in PPAR-Regulated Gene Expression. PPAR Research. 2010. Vol. 2010, no. 2010, pp.1-21.
https://search.emarefa.net/detail/BIM-457354
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457354