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Toxicology Evaluation of Realgar-Containing Niu-Huang-Jie-Du Pian as Compared to Arsenicals in Cell Cultures and in Mice
Joint Authors
Wu, Qin
Miao, Jia-Wei
Liang, Shi-Xia
Sun, An-Sheng
Liu, Jie
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Niu-Huang-Jie-Du Pian (NHJD) is a widely used traditional Chinese medicine containing realgar (As4S4).
Realgar has been included in many traditional medicines, but is often taken as arsenite for risk assessment.
To evaluate true risk of realgar and realgar-containing NHJD, their toxicity was compared with common arsenicals.
In cultured cells, the LC50 for NHJD (1200 μM) and realgar (2000 μM) was much higher than arsenite(35 μM), arsenic trioxide (280 μM), and arsenate (400 μM).
Acute toxicity in mice showed more severe liver and kidney injury after arsenite or arsenate, but was mild after realgar and NHJD, corresponding to cellular and tissue arsenic accumulation.
The expressions of arsenic-sensitive stress gene metallothionein-1 were increased 3–7-folds after arsenite or arsenate, but were unaltered after NHJD and realgar.
Thus, realgar and NHJD are much less toxic than arsenite and arsenate.
The use of total arsenic to evaluate the safety of realgar and realgar-containing NHJD is inappropriate.
American Psychological Association (APA)
Miao, Jia-Wei& Liang, Shi-Xia& Wu, Qin& Liu, Jie& Sun, An-Sheng. 2011. Toxicology Evaluation of Realgar-Containing Niu-Huang-Jie-Du Pian as Compared to Arsenicals in Cell Cultures and in Mice. ISRN Toxicology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-457378
Modern Language Association (MLA)
Miao, Jia-Wei…[et al.]. Toxicology Evaluation of Realgar-Containing Niu-Huang-Jie-Du Pian as Compared to Arsenicals in Cell Cultures and in Mice. ISRN Toxicology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-457378
American Medical Association (AMA)
Miao, Jia-Wei& Liang, Shi-Xia& Wu, Qin& Liu, Jie& Sun, An-Sheng. Toxicology Evaluation of Realgar-Containing Niu-Huang-Jie-Du Pian as Compared to Arsenicals in Cell Cultures and in Mice. ISRN Toxicology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-457378
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457378