Factor V Leiden and Prothrombin 20210A Mutations among Turkish Pediatric Leukemia Patients

Abstract EN

This study was undertaken to determine the prevalence of the Factor V 1691 G-A and PT 20210 G-A mutations in Turkish children with leukemia.

We genotyped 135 pediatric leukemia patients with for these mutations.

Eleven (8%) of the 135 patients were heterozygous for the FV 1691 G-A mutation.

Seven (5,1%) of the patients carried the PT 20210 G-A heterozygous mutation.

Of the 135 patients, only three had thrombotic event, none of which had these two mutations, which is common in Turkish population.

Our findings revealed a controversial compared to the previous reports, which needs further investigation.