The Plasminogen Receptor, Plg-RKT, and Macrophage Function
Joint Authors
Lighvani, Shahrzad
Parmer, Robert J.
Yates, John R.
Baik, Nagyung
Miles, Lindsey A.
Chen, Emily I.
Diggs, Jenna E.
Khaldoyanidi, Sophia
Kiosses, William B.
Andronicos, Nicholas M.
Kamps, Mark P.
Parmer, Caitlin M.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-14
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
When plasminogen binds to cells its activation to plasmin is markedly enhanced compared to the reaction in solution.
Thus, cells become armed with the broad spectrum proteolytic activity of plasmin.
Cell-surface plasmin plays a key role in macrophage recruitment during the inflammatory response.
Proteins exposing basic residues on the cell surface promote plasminogen activation on eukaryotic cells.
We have used a proteomics approach combining targeted proteolysis with carboxypeptidase B and multidimensional protein identification technology, MudPIT, and a monocyte progenitor cell line to identify a novel transmembrane protein, the plasminogen receptor, Plg-RKT.
Plg-RKT exposes a C-terminal lysine on the cell surface in an orientation to bind plasminogen and promote plasminogen activation.
Here we review the characteristics of this new protein, with regard to membrane topology, conservation of sequence across species, the role of its C-terminus in plasminogen binding, its function in plasminogen activation, cell migration, and its role in macrophage recruitment in the inflammatory response.
American Psychological Association (APA)
Miles, Lindsey A.& Lighvani, Shahrzad& Baik, Nagyung& Andronicos, Nicholas M.& Chen, Emily I.& Parmer, Caitlin M.…[et al.]. 2012. The Plasminogen Receptor, Plg-RKT, and Macrophage Function. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-457388
Modern Language Association (MLA)
Miles, Lindsey A.…[et al.]. The Plasminogen Receptor, Plg-RKT, and Macrophage Function. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-457388
American Medical Association (AMA)
Miles, Lindsey A.& Lighvani, Shahrzad& Baik, Nagyung& Andronicos, Nicholas M.& Chen, Emily I.& Parmer, Caitlin M.…[et al.]. The Plasminogen Receptor, Plg-RKT, and Macrophage Function. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-457388
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457388