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Immunohistochemical Expression of p53 in Pleomorphic Adenoma and Carcinoma Ex Pleomorphic Adenoma
Joint Authors
Nassani, Mohammad Z.
Kujan, Omar
Tarakji, Bassel
Source
Journal of Cancer Epidemiology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Context.
Immunohistochemical stains for p53 are used as a diagnostic marker associated with malignancy in several histologic types of salivary gland tumors.
This marker may be useful in differentiating pleomorphic adenoma (PA) from carcinoma ex pleomorphic adenoma (CPA), as these tumors are often difficult to distinguish on the basis of morphology alone.
Objective.
to evaluate whatever inactivation of tumor suppressor gene (p53) increases with the tumor progression from normal salivary tissue to PA and eventually CPA.
Design.
Paraffin blocks of 29 cases of PA, which were surrounded by normal parotid gland, and 27 cases of carcinoma ex pleomorphic adenoma were retrieved and validated.
In all cases of carcinoma ex pleomorphic adenoma, a PA “ghost” was identified, and the malignant element was either undifferentiated carcinoma or adenocarcinoma.
Results.
The results showed negative nuclear expression of P53 in normal parotid gland.
Nuclear P53 was expressed strongly in 6/29 (20.7%) pleomorphic salivary adenoma and 10/27 (37%) carcinoma ex pleomorphic adenoma.
Conclusion.
Our data suggest that inactivation of p53 may play an important role in the evolution of pleomorphic salivary adenoma and carcinoma ex pleomorphic adenoma.
American Psychological Association (APA)
Tarakji, Bassel& Kujan, Omar& Nassani, Mohammad Z.. 2010. Immunohistochemical Expression of p53 in Pleomorphic Adenoma and Carcinoma Ex Pleomorphic Adenoma. Journal of Cancer Epidemiology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-457404
Modern Language Association (MLA)
Tarakji, Bassel…[et al.]. Immunohistochemical Expression of p53 in Pleomorphic Adenoma and Carcinoma Ex Pleomorphic Adenoma. Journal of Cancer Epidemiology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-457404
American Medical Association (AMA)
Tarakji, Bassel& Kujan, Omar& Nassani, Mohammad Z.. Immunohistochemical Expression of p53 in Pleomorphic Adenoma and Carcinoma Ex Pleomorphic Adenoma. Journal of Cancer Epidemiology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-457404
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457404