Schisandrin B as a Hormetic Agent for Preventing Age-Related Neurodegenerative Diseases

Joint Authors

Lam, Philip Y.
Ko, Kam Ming

Source

Oxidative Medicine and Cellular Longevity

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-05-13

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Natural & Life Sciences (Multidisciplinary)
Biology

Abstract EN

Oxidative stress and mitochondrial dysfunction have been implicated in the pathogenesis of neurodegenerative diseases, with the latter preceding the appearance of clinical symptoms.

The energy failure resulting from mitochondrial dysfunction further impedes brain function, which demands large amounts of energy.

Schisandrin B (Sch B), an active ingredient isolated from Fructus Schisandrae, has been shown to afford generalized tissue protection against oxidative damage in various organs, including the brain, of experimental animals.

Recent experimental findings have further demonstrated that Sch B can protect neuronal cells against oxidative challenge, presumably by functioning as a hormetic agent to sustain cellular redox homeostasis and mitoenergetic capacity in neuronal cells.

The combined actions of Sch B offer a promising prospect for preventing or possibly delaying the onset of neurodegenerative diseases, as well as enhancing brain health.

American Psychological Association (APA)

Lam, Philip Y.& Ko, Kam Ming. 2012. Schisandrin B as a Hormetic Agent for Preventing Age-Related Neurodegenerative Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-457433

Modern Language Association (MLA)

Lam, Philip Y.& Ko, Kam Ming. Schisandrin B as a Hormetic Agent for Preventing Age-Related Neurodegenerative Diseases. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-457433

American Medical Association (AMA)

Lam, Philip Y.& Ko, Kam Ming. Schisandrin B as a Hormetic Agent for Preventing Age-Related Neurodegenerative Diseases. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-457433

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-457433