Schisandrin B as a Hormetic Agent for Preventing Age-Related Neurodegenerative Diseases
Joint Authors
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Oxidative stress and mitochondrial dysfunction have been implicated in the pathogenesis of neurodegenerative diseases, with the latter preceding the appearance of clinical symptoms.
The energy failure resulting from mitochondrial dysfunction further impedes brain function, which demands large amounts of energy.
Schisandrin B (Sch B), an active ingredient isolated from Fructus Schisandrae, has been shown to afford generalized tissue protection against oxidative damage in various organs, including the brain, of experimental animals.
Recent experimental findings have further demonstrated that Sch B can protect neuronal cells against oxidative challenge, presumably by functioning as a hormetic agent to sustain cellular redox homeostasis and mitoenergetic capacity in neuronal cells.
The combined actions of Sch B offer a promising prospect for preventing or possibly delaying the onset of neurodegenerative diseases, as well as enhancing brain health.
American Psychological Association (APA)
Lam, Philip Y.& Ko, Kam Ming. 2012. Schisandrin B as a Hormetic Agent for Preventing Age-Related Neurodegenerative Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-457433
Modern Language Association (MLA)
Lam, Philip Y.& Ko, Kam Ming. Schisandrin B as a Hormetic Agent for Preventing Age-Related Neurodegenerative Diseases. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-457433
American Medical Association (AMA)
Lam, Philip Y.& Ko, Kam Ming. Schisandrin B as a Hormetic Agent for Preventing Age-Related Neurodegenerative Diseases. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-457433
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457433