Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma : A Report from the Children's Oncology Group
Joint Authors
Segal, Mark
Geier, Ethan
Pawel, Bruce
Batra, Vandana
Yee, Sook Wah
Kreissman, Susan
Giacomini, Kathleen
Neuhaus, John
Martinez, Daniel
Attiyeh, Edward
Matthay, Katherine K.
London, Wendy B.
Baker, David
Naranjo, Arlene
Yanik, Greg
Maris, John M.
Hogarty, Michael D.
DuBois, Steven G.
Source
International Journal of Molecular Imaging
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
123I-metaiodobenzylguanidine (MIBG) is used for the diagnostic evaluation of neuroblastoma.
We evaluated the relationship between norepinephrine transporter (NET) expression and clinical MIBG uptake.
Methods.
Quantitative reverse transcription PCR (N=82) and immunohistochemistry (IHC; N=61) were performed for neuroblastoma NET mRNA and protein expression and correlated with MIBG avidity on diagnostic scans.
The correlation of NET expression with clinical features was also performed.
Results.
Median NET mRNA expression level for the 19 MIBG avid patients was 12.9% (range 1.6–73.7%) versus 5.9% (range 0.6–110.0%) for the 8 nonavid patients (P=0.31).
Median percent NET protein expression was 50% (range 0–100%) in MIBG avid patients compared to 10% (range 0–80%) in nonavid patients (P=0.027).
MYCN amplified tumors had lower NET protein expression compared to nonamplified tumors (10% versus 50%; P=0.0002).
Conclusions.
NET protein expression in neuroblastoma correlates with MIBG avidity.
MYCN amplified tumors have lower NET protein expression.
American Psychological Association (APA)
DuBois, Steven G.& Geier, Ethan& Batra, Vandana& Yee, Sook Wah& Neuhaus, John& Segal, Mark…[et al.]. 2012. Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma : A Report from the Children's Oncology Group. International Journal of Molecular Imaging،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-457434
Modern Language Association (MLA)
DuBois, Steven G.…[et al.]. Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma : A Report from the Children's Oncology Group. International Journal of Molecular Imaging No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-457434
American Medical Association (AMA)
DuBois, Steven G.& Geier, Ethan& Batra, Vandana& Yee, Sook Wah& Neuhaus, John& Segal, Mark…[et al.]. Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma : A Report from the Children's Oncology Group. International Journal of Molecular Imaging. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-457434
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457434