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Antiangiogenic Therapy and Mechanisms of Tumor Resistance in Malignant Glioma
Joint Authors
Grundy, Richard
Rahman, Cheryl
Rahman, Ruman
Smith, Stuart
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-11
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Despite advances in surgery, radiation therapy, and chemotherapeutics, patients with malignant glioma have a dismal prognosis.
The formations of aberrant tumour vasculature and glioma cell invasion are major obstacles for effective treatment.
Angiogenesis is a key event in the progression of malignant gliomas, a process involving endothelial cell proliferation, migration, reorganization of extracellular matrix and tube formation.
Such processes are regulated by the homeostatic balance between proangiogenic and antiangiogenic factors, most notably vascular endothelial growth factors (VEGFs) produced by glioma cells.
Current strategies targeting VEGF-VEGF receptor signal transduction pathways, though effective in normalizing abnormal tumor vasculature, eventually result in tumor resistance whereby a highly infiltrative and invasive phenotype may be adopted.
Here we review recent anti-angiogenic therapy for malignant glioma and highlight implantable devices and nano/microparticles as next-generation methods for chemotherapeutic delivery.
Intrinsic and adaptive modes of glioma resistance to anti-angiogenic therapy will be discussed with particular focus on the glioma stem cell paradigm.
American Psychological Association (APA)
Rahman, Ruman& Smith, Stuart& Rahman, Cheryl& Grundy, Richard. 2010. Antiangiogenic Therapy and Mechanisms of Tumor Resistance in Malignant Glioma. Journal of Oncology،Vol. 2010, no. 2010, pp.1-16.
https://search.emarefa.net/detail/BIM-457465
Modern Language Association (MLA)
Rahman, Ruman…[et al.]. Antiangiogenic Therapy and Mechanisms of Tumor Resistance in Malignant Glioma. Journal of Oncology No. 2010 (2010), pp.1-16.
https://search.emarefa.net/detail/BIM-457465
American Medical Association (AMA)
Rahman, Ruman& Smith, Stuart& Rahman, Cheryl& Grundy, Richard. Antiangiogenic Therapy and Mechanisms of Tumor Resistance in Malignant Glioma. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-16.
https://search.emarefa.net/detail/BIM-457465
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457465