An Obesity-Related FTO Variant and the Risk of Preeclampsia in a Finnish Study Population

Abstract EN

Previous studies have demonstrated a common variant of the obesity and fat mass-related FTO gene, rs9939609, to be associated with obesity, type 2 diabetes, and elevated blood pressure.

We investigated whether the FTO SNP rs9939609 is associated with the risk of preeclampsia (PE) in a Finnish study population.

485 women with prior PE and 449 women who had given birth after a normotensive pregnancy were genotyped (TaqMan) for the SNP rs9939609.

The prevalences of genotypes AA, AT, and TT were 15%, 53%, and 32%, respectively, among the PE cases, and 16%, 47%, and 37%, respectively, among the controls (P=0.199).

We found no evidence of an association between the FTO SNP rs9939609 and PE.

However, our cases were dominated by severe, early-onset PE.

Thus, we are unable to exclude an association with the milder, later-onset form of the disease in which the role of maternal metabolic predisposition could be more significant.Erratum to “An Obesity-Related FTO Variant and the Risk of Preeclampsia in a Finnish Study Population”dx.doi.org/10.1155/2012/540682