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A Novel Mouse Model of Alzheimer's Disease with Chronic Estrogen Deficiency Leads to Glial Cell Activation and Hypertrophy
Joint Authors
Boridy, Sebastien
Prat, Annik
Behrendt, Maik
Maysinger, Dusica
Seidah, Nabil G.
Marcinkiewicz, Edwige
Sairam, Ram M.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
The role of estrogens in Alzheimer's disease (AD) involving β-amyloid (Aβ) generation and plaque formation was mostly tested in ovariectomized mice with or without APP mutations.
The aim of the present study was to explore the abnormalities of neural cells in a novel mouse model of AD with chronic estrogen deficiency.
These chimeric mice exhibit a total FSH-R knockout (FORKO) and carry two transgenes, one expressing the β-amyloid precursor protein (APPsw, Swedish mutation) and the other expressing presenilin-1 lacking exon 9 (PS1Δ9).
The most prominent changes in the cerebral cortex and hippocampus of these hypoestrogenic mice were marked hypertrophy of both cortical neurons and astrocytes and an increased number of activated microglia.
There were no significant differences in the number of Aβ plaques although they appeared less compacted and larger than those in APPsw/PS1Δ9 control mice.
Similar glia abnormalities were obtained in wild-type primary cortical neural cultures treated with letrozole, an aromatase inhibitor.
The concordance of results from APPsw/PS1Δ9 mice with or without FSH-R deletion and those with letrozole treatment in vitro (with and without Aβ treatment) of primary cortical/hippocampal cultures suggests the usefulness of these models to explore molecular mechanisms involved in microglia and astrocyte activation in hypoestrogenic states in the central nervous system.
American Psychological Association (APA)
Prat, Annik& Behrendt, Maik& Marcinkiewicz, Edwige& Boridy, Sebastien& Sairam, Ram M.& Seidah, Nabil G.…[et al.]. 2011. A Novel Mouse Model of Alzheimer's Disease with Chronic Estrogen Deficiency Leads to Glial Cell Activation and Hypertrophy. Journal of Aging Research،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-457496
Modern Language Association (MLA)
Prat, Annik…[et al.]. A Novel Mouse Model of Alzheimer's Disease with Chronic Estrogen Deficiency Leads to Glial Cell Activation and Hypertrophy. Journal of Aging Research No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-457496
American Medical Association (AMA)
Prat, Annik& Behrendt, Maik& Marcinkiewicz, Edwige& Boridy, Sebastien& Sairam, Ram M.& Seidah, Nabil G.…[et al.]. A Novel Mouse Model of Alzheimer's Disease with Chronic Estrogen Deficiency Leads to Glial Cell Activation and Hypertrophy. Journal of Aging Research. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-457496
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457496