The Inhibitory Effect of Somatostatin Receptor Activation on Bee Venom-Evoked Nociceptive Behavior and pCREB Expression in Rats
Joint Authors
Ma, Shaojie
Yao, Fanrong
Guo, Yuan
Wang, Jun
Li, Li
Wang, Huisheng
Cao, Dongyuan
Luo, Rong
Zhao, Yan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The present study examined nociceptive behaviors and the expression of phosphorylated cAMP response element-binding protein (pCREB) in the dorsal horn of the lumbar spinal cord and the dorsal root ganglion (DRG) evoked by bee venom (BV).
The effect of intraplantar preapplication of the somatostatin analog octreotide on nociceptive behaviors and pCREB expression was also examined.
Subcutaneous injection of BV into the rat unilateral hindpaw pad induced significant spontaneous nociceptive behaviors, primary mechanical allodynia, primary thermal hyperalgesia, and mirror-thermal hyperalgesia, as well as an increase in pCREB expression in the lumbar spinal dorsal horn and DRG.
Octreotide pretreatment significantly attenuated the BV-induced lifting/licking response and mechanical allodynia.
Local injection of octreotide also significantly reduced pCREB expression in the lumbar spinal dorsal horn and DRG.
Furthermore, pretreatment with cyclosomatostatin, a somatostatin receptor antagonist, reversed the octreotide-induced inhibition of the lifting/licking response, mechanical allodynia, and the expression of pCREB.
These results suggest that BV can induce nociceptive responses and somatostatin receptors are involved in mediating the antinociception, which provides new evidence for peripheral analgesic action of somatostatin in an inflammatory pain state.
American Psychological Association (APA)
Li, Li& Luo, Rong& Guo, Yuan& Yao, Fanrong& Cao, Dongyuan& Ma, Shaojie…[et al.]. 2014. The Inhibitory Effect of Somatostatin Receptor Activation on Bee Venom-Evoked Nociceptive Behavior and pCREB Expression in Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-457536
Modern Language Association (MLA)
Li, Li…[et al.]. The Inhibitory Effect of Somatostatin Receptor Activation on Bee Venom-Evoked Nociceptive Behavior and pCREB Expression in Rats. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-457536
American Medical Association (AMA)
Li, Li& Luo, Rong& Guo, Yuan& Yao, Fanrong& Cao, Dongyuan& Ma, Shaojie…[et al.]. The Inhibitory Effect of Somatostatin Receptor Activation on Bee Venom-Evoked Nociceptive Behavior and pCREB Expression in Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-457536
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457536