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An Efficient Approach to the Synthesis of Novel Oxazolidinones as Potential Antimicrobial Agents
Joint Authors
Dwivedi, Jaya
Jain, Sonika
Devi, Kavita
Asmat, Yumna
Sharma, Swapnil
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Oxazolidinone, either mononuclear or condensed with other heterocyclics, has established its importance in medicinal chemistry.
A variety of biological activities have been reported by oxazolidinone derivatives.
The present work describes the synthesis of several oxazolidinone derivatives, 3-(2-(7-chloroquinoline-4-ylamino)ethyl)-2-imino-5-(4-chloro/nitro/methoxy benzylidene)oxazolidin-4-one 4(a–c) and 4-(2-(7-chloroquinolin-4-ylamino)ethyl)-2(4-chloro/nitro/methoxy-benzylidene)-1,6-diox-4,9-di-azaspiro[4,4]nonane-3,8-dione 5(a–c).
Synthesized compounds (1, 3, 4a, 5a, and 5c) were screened against bacterial strains such as S.
aureus (MTCC 96) and E.
coli (MTCC119) and fungal strains A.
niger (MTCC 1344) and C.
albicans (MTCC 871) compared with penicillin for bacteria and fluconazole for fungi as reference drugs by disk diffusion method.
All synthesized compounds were identified by the means of IR, NMR, and MS.
American Psychological Association (APA)
Devi, Kavita& Asmat, Yumna& Jain, Sonika& Sharma, Swapnil& Dwivedi, Jaya. 2012. An Efficient Approach to the Synthesis of Novel Oxazolidinones as Potential Antimicrobial Agents. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-457568
Modern Language Association (MLA)
Devi, Kavita…[et al.]. An Efficient Approach to the Synthesis of Novel Oxazolidinones as Potential Antimicrobial Agents. Journal of Chemistry No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-457568
American Medical Association (AMA)
Devi, Kavita& Asmat, Yumna& Jain, Sonika& Sharma, Swapnil& Dwivedi, Jaya. An Efficient Approach to the Synthesis of Novel Oxazolidinones as Potential Antimicrobial Agents. Journal of Chemistry. 2012. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-457568
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457568