Synthesis and Biological Evaluation of New CRH Analogues
Joint Authors
Pairas, George
Martinez, Jean
Papazacharias, Spyridon
Cordopatis, Paul
Bernad, Nicole
Spyroulias, Georgios A.
Magafa, Vassiliki
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A series of 7 new human/rat Corticotropin Releasing Hormone (h/r-CRH) analogues were synthesized.
The induced alterations include substitution of Phe at position 12 with D-Phe, Leu at positions 14 and 15 with Aib and Met at positions 21 and 38 with Cys(Et) and Cys(Pr).
The analogues were tested regarding their binding affinity to the CRH-1 receptor and their activity which is represented by means of percentage of maximum response in comparison to the native molecule.
The results indicated that the introduction of Aib, or Cys derivatives although altering the secondary structure of the molecule, did not hinder receptor recognition and binding.
American Psychological Association (APA)
Papazacharias, Spyridon& Magafa, Vassiliki& Bernad, Nicole& Pairas, George& Spyroulias, Georgios A.& Martinez, Jean…[et al.]. 2010. Synthesis and Biological Evaluation of New CRH Analogues. Bioinorganic Chemistry and Applications،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-457573
Modern Language Association (MLA)
Papazacharias, Spyridon…[et al.]. Synthesis and Biological Evaluation of New CRH Analogues. Bioinorganic Chemistry and Applications No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-457573
American Medical Association (AMA)
Papazacharias, Spyridon& Magafa, Vassiliki& Bernad, Nicole& Pairas, George& Spyroulias, Georgios A.& Martinez, Jean…[et al.]. Synthesis and Biological Evaluation of New CRH Analogues. Bioinorganic Chemistry and Applications. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-457573
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457573
