![](/images/graphics-bg.png)
PTEN Gene : A Model for Genetic Diseases in Dermatology
Joint Authors
Schepis, Carmelo
Romano, Corrado
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
PTEN gene is considered one of the most mutated tumor suppressor genes in human cancer, and it’s likely to become the first one in the near future.
Since 1997, its involvement in tumor suppression has smoothly increased, up to the current importance.
Germline mutations of PTEN cause the PTEN hamartoma tumor syndrome (PHTS), which include the past-called Cowden, Bannayan-Riley-Ruvalcaba, Proteus, Proteus-like, and Lhermitte-Duclos syndromes.
Somatic mutations of PTEN have been observed in glioblastoma, prostate cancer, and brest cancer cell lines, quoting only the first tissues where the involvement has been proven.
The negative regulation of cell interactions with the extracellular matrix could be the way PTEN phosphatase acts as a tumor suppressor.
PTEN gene plays an essential role in human development.
A recent model sees PTEN function as a stepwise gradation, which can be impaired not only by heterozygous mutations and homozygous losses, but also by other molecular mechanisms, such as transcriptional regression, epigenetic silencing, regulation by microRNAs, posttranslational modification, and aberrant localization.
The involvement of PTEN function in melanoma and multistage skin carcinogenesis, with its implication in cancer treatment, and the role of front office in diagnosing PHTS are the main reasons why the dermatologist should know about PTEN.
American Psychological Association (APA)
Romano, Corrado& Schepis, Carmelo. 2012. PTEN Gene : A Model for Genetic Diseases in Dermatology. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-457582
Modern Language Association (MLA)
Romano, Corrado& Schepis, Carmelo. PTEN Gene : A Model for Genetic Diseases in Dermatology. The Scientific World Journal No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-457582
American Medical Association (AMA)
Romano, Corrado& Schepis, Carmelo. PTEN Gene : A Model for Genetic Diseases in Dermatology. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-457582
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457582