(R)‎-α-Aminoadipic Acid : A Versatile Precursor for the Synthesis of D-Amino Acids

Abstract EN

The ready accessibility of (R)-α-aminoadipic acid by enzymatic cleavage of cephalosporin C (CephC) in the production of 7-aminocephalosporanic acid (7-ACA) on a large scale makes it a favorable chiral pool building block for the synthesis of unusual amino acids.

A route for the synthesis of C-5-alkenyl and C-6-alkylidene derivatives of (R)-pipecolic acid is described which utilizes (R)-α-aminoadipic acid as the enantiomerically pure starting material.

Moreover, the synthesis of azido and triazolyl derivatives of (R)-α-aminoadipic acid is reported.