AMPK as Target for Intervention in Childhood and Adolescent Obesity
Joint Authors
Velasco, Manuel
Rojas, Joselyn
Bermúdez, Valmore
Arraiz, Nailet
Aguirre, Miguel
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-22
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Childhood obesity is a major worldwide health problem.
Intervention programs to ameliorate the rate of obesity have been designed and implemented; yet the epidemic has no end near in sight.
AMP-activated protein kinase (AMPK) has become one of the most important key elements in energy control, appetite regulation, myogenesis, adipocyte differentiation, and cellular stress management.
Obesity is a multifactorial disease, which has a very strong genetic component, especially epigenetic factors.
The intrauterine milieu has a determinant impact on adult life, since the measures taken for survival are kept throughout life thanks to epigenetic modification.
Nutrigenomics studies the influence of certain food molecules on the metabolome profile, raising the question of an individualized obesity therapy according to metabolic (and probably) genetic features.
Metformin, an insulin sensitizing agent, its known to lower insulin resistance and enhance metabolic profile, with an additional weight reduction capacity, via activation of AMPK.
Exercise is coadjutant for lifestyle modifications, which also activates AMPK in several ways contributing to glucose and fat oxidation.
The following review examines AMPK's role in obesity, applying its use as a tool for childhood and adolescent obesity.
American Psychological Association (APA)
Rojas, Joselyn& Arraiz, Nailet& Aguirre, Miguel& Velasco, Manuel& Bermúdez, Valmore. 2010. AMPK as Target for Intervention in Childhood and Adolescent Obesity. Journal of Obesity،Vol. 2011, no. 2011, pp.1-19.
https://search.emarefa.net/detail/BIM-457609
Modern Language Association (MLA)
Rojas, Joselyn…[et al.]. AMPK as Target for Intervention in Childhood and Adolescent Obesity. Journal of Obesity No. 2011 (2011), pp.1-19.
https://search.emarefa.net/detail/BIM-457609
American Medical Association (AMA)
Rojas, Joselyn& Arraiz, Nailet& Aguirre, Miguel& Velasco, Manuel& Bermúdez, Valmore. AMPK as Target for Intervention in Childhood and Adolescent Obesity. Journal of Obesity. 2010. Vol. 2011, no. 2011, pp.1-19.
https://search.emarefa.net/detail/BIM-457609
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457609