Differential Effects of Acute (Extenuating) and Chronic (Training) Exercise on Inflammation and Oxidative Stress Status in an Animal Model of Type 2 Diabetes Mellitus
Joint Authors
Pinto, Rui
Teixeira, Frederico
Sereno, José
Mascarenhas-Melo, Filipa
Teixeira de Lemos, Edite
Páscoa-Pinheiro, João
Oliveira, Jorge
Garrido, Patrícia
Reis, Flávio
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study compares the effects of a single bout of exercise (acute extenuating) with those promoted by an exercise training program (chronic), focusing on low-grade chronic inflammation profile and on oxidative stress status, using the obese ZDF rats as a model of type 2 diabetes mellitus (T2DM).
Animals were sacrificed after 12 weeks of a swimming training program and after a single bout of acute extenuating exercise.
Glycaemic, insulinemic, and lipidic profile (triglycerides, total-cholesterol) were evaluated, as well as inflammatory (serum CRPhs, TNF-α, adiponectin) and oxidative (lipidic peroxidation and uric acid) status.
When compared to obese diabetic sedentary rats, the animals submitted to acute exercise presented significantly lower values of glycaemia and insulinaemia, with inflammatory profile and oxidative stress significantly aggravated.
The trained animals showed amelioration of glycaemic and lipidic dysmetabolism, accompanied by remarkable reduction of inflammatory and oxidative markers.
In conclusion, the results presented herein suggessted that exercise pathogenesis-oriented interventions should not exacerbate underlying inflammatory stress associated with T2DM.
American Psychological Association (APA)
Teixeira de Lemos, Edite& Pinto, Rui& Oliveira, Jorge& Garrido, Patrícia& Sereno, José& Mascarenhas-Melo, Filipa…[et al.]. 2011. Differential Effects of Acute (Extenuating) and Chronic (Training) Exercise on Inflammation and Oxidative Stress Status in an Animal Model of Type 2 Diabetes Mellitus. Mediators of Inflammation،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-457631
Modern Language Association (MLA)
Teixeira de Lemos, Edite…[et al.]. Differential Effects of Acute (Extenuating) and Chronic (Training) Exercise on Inflammation and Oxidative Stress Status in an Animal Model of Type 2 Diabetes Mellitus. Mediators of Inflammation No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-457631
American Medical Association (AMA)
Teixeira de Lemos, Edite& Pinto, Rui& Oliveira, Jorge& Garrido, Patrícia& Sereno, José& Mascarenhas-Melo, Filipa…[et al.]. Differential Effects of Acute (Extenuating) and Chronic (Training) Exercise on Inflammation and Oxidative Stress Status in an Animal Model of Type 2 Diabetes Mellitus. Mediators of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-457631
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457631