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Clinical Factors Associated with Response or Survival after Chemotherapy in Patients with Waldenström Macroglobulinemia in Korea
Joint Authors
Lee, Jeong-Ok
Lee, Won Sik
Lee, Jae Hoon
Hong, Junshik
Bang, Soo-Mee
Eom, Hyeon-Seok
Do, Young Rok
Bae, Sung Hwa
Kim, Se Hyung
Kim, Inho
Mun, Yeung-Chul
Yoon, Dok Hyun
Shin, Ho-Jin
Lee, Ho Sup
Lee, Mark Hong
Kim, Jin Seok
Lee, Ji Hyun
Min, Chang-Ki
Lee, Hyewon
Kim, Kihyun
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Waldenström’s macroglobulinemia (WM) is a B-cell proliferative malignancy characterized by immunoglobulin M monoclonal gammopathy and bone marrow infiltration by lymphoplasmacytic cells.
Clinical features and cytogenetics of WM in Asia including Republic of Korea remain unclear.
Moreover, no study has reported treatment outcomes in patients with WM treated with novel agent combined with conventional chemotherapy.
This study investigated clinical features and assessed treatment outcomes with novel agent and conventional chemotherapy in Republic of Korea.
Data from all (n=71) patients with newly diagnosed WM at 17 hospitals who received chemotherapy between January 2005 and December 2012 were collected retrospectively.
The median age of patients was 66 years (range: 37–92 years) and male to female ratio was 5 : 1.
Patients treated with novel agent combined chemotherapy displayed higher overall response rate (ORR) compared to conventional chemotherapy alone (92.9% versus 52.6%, P=0.006).
The 5-year overall survival rate was 62.6% (95% confidence interval: 34.73–111.07).
Use of novel agents produced higher ORR but survival benefit was not apparent due to the small number of patients and short follow-up duration.
Further studies are needed to confirm the efficacy of novel agents in patients with WM.
American Psychological Association (APA)
Lee, Ho Sup& Kim, Kihyun& Yoon, Dok Hyun& Kim, Jin Seok& Bang, Soo-Mee& Lee, Jeong-Ok…[et al.]. 2014. Clinical Factors Associated with Response or Survival after Chemotherapy in Patients with Waldenström Macroglobulinemia in Korea. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-457645
Modern Language Association (MLA)
Lee, Ho Sup…[et al.]. Clinical Factors Associated with Response or Survival after Chemotherapy in Patients with Waldenström Macroglobulinemia in Korea. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-457645
American Medical Association (AMA)
Lee, Ho Sup& Kim, Kihyun& Yoon, Dok Hyun& Kim, Jin Seok& Bang, Soo-Mee& Lee, Jeong-Ok…[et al.]. Clinical Factors Associated with Response or Survival after Chemotherapy in Patients with Waldenström Macroglobulinemia in Korea. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-457645
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457645