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Pathological Diagnosis of Hepatocellular Cellular Adenoma according to the Clinical Context
Joint Authors
Frédéric Blanc, Jean
Bioulac-Sage, Paulette
Laurent, Christophe
Laumonier, Hervé
Le Bail, Brigitte
Frulio, Nora
Chiche, Laurence
Balabaud, Charles
Sempoux, Christine
Saric, Jean
Trillaud, Hervé
Possenti, Laurent
Source
International Journal of Hepatology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
In Europe and North America, hepatocellular adenomas (HCA) occur, classically, in middle-aged woman taking oral contraceptives.
Twenty percent of women, however, are not exposed to oral contraceptives; HCA can more rarely occur in men, children, and women over 65 years.
HCA have been observed in many pathological conditions such as glycogenosis, familial adenomatous polyposis, MODY3, after male hormone administration, and in vascular diseases.
Obesity is frequent particularly in inflammatory HCA.
The background liver is often normal, but steatosis is a frequent finding particularly in inflammatory HCA.
The diagnosis of HCA is more difficult when the background liver is fibrotic, notably in vascular diseases.
HCA can be solitary, or multiple or in great number (adenomatosis).
When nodules are multiple, they are usually of the same subtype.
HNF1α-inactivated HCA occur almost exclusively in woman.
The most important point of the classification is the identification of β-catenin mutated HCA, a strong argument to identify patients at risk of malignant transformation.
Some HCA already present criteria indicating malignant transformation.
When the whole nodule is a hepatocellular carcinoma, it is extremely difficult to prove that it is the consequence of a former HCA.
It is occasionally difficult to identify HCA remodeled by necrosis or hemorrhage.
American Psychological Association (APA)
Bioulac-Sage, Paulette& Sempoux, Christine& Possenti, Laurent& Frulio, Nora& Laumonier, Hervé& Laurent, Christophe…[et al.]. 2013. Pathological Diagnosis of Hepatocellular Cellular Adenoma according to the Clinical Context. International Journal of Hepatology،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-457647
Modern Language Association (MLA)
Bioulac-Sage, Paulette…[et al.]. Pathological Diagnosis of Hepatocellular Cellular Adenoma according to the Clinical Context. International Journal of Hepatology No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-457647
American Medical Association (AMA)
Bioulac-Sage, Paulette& Sempoux, Christine& Possenti, Laurent& Frulio, Nora& Laumonier, Hervé& Laurent, Christophe…[et al.]. Pathological Diagnosis of Hepatocellular Cellular Adenoma according to the Clinical Context. International Journal of Hepatology. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-457647
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457647