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Effects of Mixture of Pharmaceuticals on Early Life Stages of Tench (Tinca tinca)
Joint Authors
Maršálek, Petr
Bartoskova, Marta
Zivna, Dana
Prokeš, Miroslav
Plhalova, Lucie
Stancova, Vlasta
Škorič, Miša
Svobodova, Zdenka
Blahová, Jana
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Ubiquitous occurrence of pharmaceuticals in aquatic environment results in concern about potential adverse the effects on nontarget organisms.
In water, drugs are present in complex mixtures, in which complicated interactions affect toxicity of single components.
The purpose of this study was to examine effect of 35-day-long exposure to mixture of ibuprofen, diclofenac, and carbamazepine on the mortality, growth, early ontogeny, and histopathological changes in tench (Tinca tinca).
Early life stage toxicity test was carried out using a modified protocol according to OECD guideline 210.
Exposure to mixture of pharmaceuticals at concentration of 60 μg·L−1 for each substance was associated with significant increase in mortality, as well as significant increase in growth and elevated incidence of malformations.
Any of the tested concentrations resulted in histopathological changes of liver, kidney, skin, or gill.
After fourteen days of exposure there was short-term delay of development related to increased concentrations of pharmaceuticals in the mixture (2, 20, and 60 μg·L−1).
Environmentally relevant concentrations (0.02; and 0.2 μg·L−1) used in this experiment did not result in toxic impairment of tench.
American Psychological Association (APA)
Stancova, Vlasta& Plhalova, Lucie& Bartoskova, Marta& Zivna, Dana& Prokeš, Miroslav& Maršálek, Petr…[et al.]. 2014. Effects of Mixture of Pharmaceuticals on Early Life Stages of Tench (Tinca tinca). BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-457655
Modern Language Association (MLA)
Stancova, Vlasta…[et al.]. Effects of Mixture of Pharmaceuticals on Early Life Stages of Tench (Tinca tinca). BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-457655
American Medical Association (AMA)
Stancova, Vlasta& Plhalova, Lucie& Bartoskova, Marta& Zivna, Dana& Prokeš, Miroslav& Maršálek, Petr…[et al.]. Effects of Mixture of Pharmaceuticals on Early Life Stages of Tench (Tinca tinca). BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-457655
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457655