Anti-Inflammatory Effects of Interleukin-19 in Vascular Disease
Joint Authors
Autieri, Michael V.
England, Ross N.
Source
International Journal of Inflammation
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Despite aggressive dietary modification, lipid-lowering medications, and other interventional medical therapy, vascular disease continues to be a leading cause of mortality in the western world.
It is a significant medical and socioeconomic problem contributing to mortality of multiple diseases including myocardial infarction, stroke, renal failure, and peripheral vascular disease.
Morbidity and mortality of vascular disease are expected to worsen with the increasing number of patients with comorbid conditions such as obesity, metabolic syndrome, and diabetes mellitus type 2.
Vascular diseases such as atherosclerosis, restenosis, and allograft vasculopathy are recognized to be driven by inflammation, and as such, cytokines which mediate inflammation not only represent important targets of rational therapy, but also can be considered as possible therapeutic modalities themselves.
In this paper, we will examine the role of inflammatory cytokines and lymphocyte Th1/Th2 polarity in vascular inflammation, with a focus on atherosclerotic vascular disease.
We will then introduce a recently described Th2 interleukin, interleukin-19 (IL-19), as a previously unrecognized mediator of vascular inflammatory disorders.
We will review our current understanding of this interleukin in health and disease and present the possibility that IL-19 could represent a potential therapeutic to combat vascular inflammatory disease.
American Psychological Association (APA)
England, Ross N.& Autieri, Michael V.. 2012. Anti-Inflammatory Effects of Interleukin-19 in Vascular Disease. International Journal of Inflammation،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-457668
Modern Language Association (MLA)
England, Ross N.& Autieri, Michael V.. Anti-Inflammatory Effects of Interleukin-19 in Vascular Disease. International Journal of Inflammation No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-457668
American Medical Association (AMA)
England, Ross N.& Autieri, Michael V.. Anti-Inflammatory Effects of Interleukin-19 in Vascular Disease. International Journal of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-457668
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457668