Osteoconductive Potential of Barrier NanoSiO2 PLGA Membranes Functionalized by Plasma Enhanced Chemical Vapour Deposition
Joint Authors
Terriza, Antonia
González-Elipe, Agustin R.
Yubero, Francisco
Gonzalez-Caballero, Juan L.
de la Orden, Emilio
Salido, Mercedes
Vilches-Pérez, Jose I.
Vilches, José
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The possibility of tailoring membrane surfaces with osteoconductive potential, in particular in biodegradable devices, to create modified biomaterials that stimulate osteoblast response should make them more suitable for clinical use, hopefully enhancing bone regeneration.
Bioactive inorganic materials, such as silica, have been suggested to improve the bioactivity of synthetic biopolymers.
An in vitro study on HOB human osteoblasts was performed to assess biocompatibility and bioactivity of SiO2 functionalized poly(lactide-co-glycolide) (PLGA) membranes, prior to clinical use.
A 15 nm SiO2 layer was deposited by plasma enhanced chemical vapour deposition (PECVD), onto a resorbable PLGA membrane.
Samples were characterized by X-ray photoelectron spectroscopy, atomic force microscopy, scanning electron microscopy, and infrared spectroscopy (FT-IR).
HOB cells were seeded on sterilized test surfaces where cell morphology, spreading, actin cytoskeletal organization, and focal adhesion expression were assessed.
As proved by the FT-IR analysis of samples, the deposition by PECVD of the SiO2 onto the PLGA membrane did not alter the composition and other characteristics of the organic membrane.
A temporal and spatial reorganization of cytoskeleton and focal adhesions and morphological changes in response to SiO2 nanolayer were identified in our model.
The novedous SiO2 deposition method is compatible with the standard sterilization protocols and reveals as a valuable tool to increase bioactivity of resorbable PLGA membranes.
American Psychological Association (APA)
Terriza, Antonia& Vilches-Pérez, Jose I.& de la Orden, Emilio& Yubero, Francisco& Gonzalez-Caballero, Juan L.& González-Elipe, Agustin R.…[et al.]. 2014. Osteoconductive Potential of Barrier NanoSiO2 PLGA Membranes Functionalized by Plasma Enhanced Chemical Vapour Deposition. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-457669
Modern Language Association (MLA)
Terriza, Antonia…[et al.]. Osteoconductive Potential of Barrier NanoSiO2 PLGA Membranes Functionalized by Plasma Enhanced Chemical Vapour Deposition. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-457669
American Medical Association (AMA)
Terriza, Antonia& Vilches-Pérez, Jose I.& de la Orden, Emilio& Yubero, Francisco& Gonzalez-Caballero, Juan L.& González-Elipe, Agustin R.…[et al.]. Osteoconductive Potential of Barrier NanoSiO2 PLGA Membranes Functionalized by Plasma Enhanced Chemical Vapour Deposition. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-457669
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457669