![](/images/graphics-bg.png)
The Role of Arterioles and the Microcirculation in the Development of Vasospasm after Aneurysmal SAH
Joint Authors
Naraoka, Masato
Asano, Kenichiro
Shimamura, Norihito
Matsuda, Naoya
Ohkuma, Hiroki
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cerebral vasospasm of the major cerebral arteries, which is characterized by angiographic narrowing of those vessels, had been recognized as a main contributor to delayed cerebral ischemia (DCI) in subarachnoid hemorrhage (SAH) patients.
However, the CONSCIOUS-1 trial revealed that clazosentan could not improve mortality or clinical outcome in spite of successful reduction of relative risk in angiographic vasospasm.
This result indicates that the pathophysiology underlying DCI is multifactorial and that other pathophysiological factors, which are independent of angiographic vasospasm, can contribute to the outcome.
Recent studies have focused on microcirculatory disturbance, such as microthrombosis and arteriolar constriction, as a factor affecting cerebral ischemia after SAH.
Reports detecting microthrombosis and arteriolar constriction will be reviewed, and the role of the microcirculation on cerebral ischemia during vasospasm after SAH will be discussed.
American Psychological Association (APA)
Naraoka, Masato& Matsuda, Naoya& Shimamura, Norihito& Asano, Kenichiro& Ohkuma, Hiroki. 2014. The Role of Arterioles and the Microcirculation in the Development of Vasospasm after Aneurysmal SAH. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-457687
Modern Language Association (MLA)
Naraoka, Masato…[et al.]. The Role of Arterioles and the Microcirculation in the Development of Vasospasm after Aneurysmal SAH. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-457687
American Medical Association (AMA)
Naraoka, Masato& Matsuda, Naoya& Shimamura, Norihito& Asano, Kenichiro& Ohkuma, Hiroki. The Role of Arterioles and the Microcirculation in the Development of Vasospasm after Aneurysmal SAH. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-457687
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457687