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Statins Decrease Oxidative Stress and ICD Therapies
Joint Authors
Veledar, Emir
Shukrullah, Irfan
Bloom, Heather L.
Dudley, Samuel C.
London, Barry
Gutmann, Rebecca
Source
Cardiology Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Recent studies demonstrate that statins decrease ventricular arrhythmias in internal cardioverter defibrillator (ICD) patients.
The mechanism is unknown, but evidence links increased inflammatory and oxidative states with increased arrhythmias.
We hypothesized that statin use decreases oxidation.
Methods.
304 subjects with ICDs were surveyed for ventricular arrhythmia.
Blood was analyzed for derivatives of reactive oxygen species (DROMs) and interleukin-6 (IL-6).
Results.
Subjects included 252 (83%) men, 58% on statins, 20% had ventricular arrhythmias.
Average age was 63 years and ejection fraction (EF) 20%.
ICD implant duration was 29 ± 27 months.
Use of statins correlated with lower ICD events (r=0.12, P=.02).
Subjects on statins had lower hsCRP (5.2 versus 6.3; P=.05) and DROM levels (373 versus 397; P=.03).
Other factors, including IL-6 and EF did not differ between statin and nonstatin use, nor did beta-blocker or antiarrhythmic use.
Multivariate cross-correlation analysis demonstrated that DROMs, statins, IL-6 and EF were strongly associated with ICD events.
Multivariate regression shows DROMs to be the dominant predictor.
Conclusion.
ICD event rate correlates with DROMs, a measure of lipid peroxides.
Use of statins is associated with reduced DROMs and fewer ICD events, suggesting that statins exert their effect through reducing oxidation.
American Psychological Association (APA)
Bloom, Heather L.& Shukrullah, Irfan& Veledar, Emir& Gutmann, Rebecca& London, Barry& Dudley, Samuel C.. 2010. Statins Decrease Oxidative Stress and ICD Therapies. Cardiology Research and Practice،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-457692
Modern Language Association (MLA)
Bloom, Heather L.…[et al.]. Statins Decrease Oxidative Stress and ICD Therapies. Cardiology Research and Practice No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-457692
American Medical Association (AMA)
Bloom, Heather L.& Shukrullah, Irfan& Veledar, Emir& Gutmann, Rebecca& London, Barry& Dudley, Samuel C.. Statins Decrease Oxidative Stress and ICD Therapies. Cardiology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-457692
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457692