High-Resolution Imaging of Dendrimers Used in Drug Delivery via Scanning Probe Microscopy
Joint Authors
Luo, Juntao
Lam, Kit S.
Yin, Nai-Ning
Liu, Gang-yu
Riechers, Shawn L.
Fleming, Christopher J.
Shi, Lifang
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Dendrimers and telodendrimer micelles represent two new classes of vehicles for drug delivery that have attracted much attention recently.
Their structural characterization at the molecular and submolecular level remains a challenge due to the difficulties in reaching high resolution when imaging small particles in their native media.
This investigation offers a new approach towards this challenge, using scanning tunneling microscopy (STM) and atomic force microscopy (AFM).
By using new sample preparation protocols, this work demonstrates that (a) intramolecular features such as drug molecules and dendrimer termini can be resolved; and (b) telodendrimer micelles can be immobilized on the surface without compromising structural integrity, and as such, high resolution AFM imaging may be performed to attain 3D information.
This high-resolution structural information should enhance our knowledge of the nanocarrier structure and nanocarrier-drug interaction and, therefore, facilitate design and optimization of the efficiency in drug delivery.
American Psychological Association (APA)
Shi, Lifang& Fleming, Christopher J.& Riechers, Shawn L.& Yin, Nai-Ning& Luo, Juntao& Lam, Kit S.…[et al.]. 2011. High-Resolution Imaging of Dendrimers Used in Drug Delivery via Scanning Probe Microscopy. Journal of Drug Delivery،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-457731
Modern Language Association (MLA)
Shi, Lifang…[et al.]. High-Resolution Imaging of Dendrimers Used in Drug Delivery via Scanning Probe Microscopy. Journal of Drug Delivery No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-457731
American Medical Association (AMA)
Shi, Lifang& Fleming, Christopher J.& Riechers, Shawn L.& Yin, Nai-Ning& Luo, Juntao& Lam, Kit S.…[et al.]. High-Resolution Imaging of Dendrimers Used in Drug Delivery via Scanning Probe Microscopy. Journal of Drug Delivery. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-457731
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457731