Morphological and Histopathological Changes in Orofacial Structures of Experimentally Developed Acromegaly-Like Rats : An Overview
Joint Authors
Sasano, Takashi
Sakamoto, Maya
Ikeda, Hidetoshi
Iikubo, Masahiro
Kobayashi, Akane
Kojima, Ikuho
Source
International Journal of Endocrinology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Tongue enlargement and mandibular prognathism are clinically recognized in almost all patients with acromegaly.
An acromegaly-like rat model recently developed by exogenous administration of insulin-like growth factor I (IGF-I) was used to investigate morphological and histopathological changes in orofacial structures and to clarify whether these changes were reversible.
Exogenous administration of IGF-I evoked specific enlargement of the tongue with identifiable histopathological changes (increased muscle bundle width, increased space between muscle bundles, and increased epithelial thickness), elongation of the mandibular alveolar bone and ascending ramus, and lateral expansion of the mandibular dental arch.
Regarding histopathological changes in the mandibular condyle, the cartilaginous layer width, bone matrix ratio, and number of osteoblasts were all significantly greater in this rat model.
After normalization of the circulating IGF-I level, tongue enlargement and histopathological changes in the tongue and mandibular condyle were reversible, whereas morphological skeletal changes in the mandible remained.
American Psychological Association (APA)
Iikubo, Masahiro& Kojima, Ikuho& Sakamoto, Maya& Kobayashi, Akane& Ikeda, Hidetoshi& Sasano, Takashi. 2012. Morphological and Histopathological Changes in Orofacial Structures of Experimentally Developed Acromegaly-Like Rats : An Overview. International Journal of Endocrinology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-457758
Modern Language Association (MLA)
Iikubo, Masahiro…[et al.]. Morphological and Histopathological Changes in Orofacial Structures of Experimentally Developed Acromegaly-Like Rats : An Overview. International Journal of Endocrinology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-457758
American Medical Association (AMA)
Iikubo, Masahiro& Kojima, Ikuho& Sakamoto, Maya& Kobayashi, Akane& Ikeda, Hidetoshi& Sasano, Takashi. Morphological and Histopathological Changes in Orofacial Structures of Experimentally Developed Acromegaly-Like Rats : An Overview. International Journal of Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-457758
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457758