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Outcome of Acute Renal Injury in Diabetic Mice with Experimental Endotoxemia : Role of Hypoxia-Inducible Factor-1α
Joint Authors
Olea, Nuria
Arenas, María Isabel
Arribas, Ignacio
García-Bermejo, L.
Ortega, Arantxa
Muñóz-Moreno, C.
Bosch, Ricardo J.
Lucio-Cazana, J.
Fernández, A.
López-Luna, P.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The role of diabetic nephropathy in the outcome of acute renal injury (AKI) is not well defined.
Herein we evaluate the outcome of lipopolysaccharide- (LPS-) induced AKI in streptozotocin-induced diabetes, as well as the potential role of Hypoxia Inducible Factor (HIF-1α) in this condition.
Although 6 h after LPS injection all mice developed a decrease in renal function, proteinuric diabetic mice showed a better recovery of this parameter throughout the study (72 h).
Both HIF-1α and vascular endothelium growth factor (VEGF) were found to be upregulated in diabetic mice.
After LPS injection, all animals showed an upregulation of these factors, although it was higher in the diabetic group.
Glycated albumin (GA) was found to upregulate HIF-1α in HK-2 cells, which resulted in increased production of VEGF.
Interestingly, LPS cooperated with GA to induce HIF-1α upregulation.
In conclusion, diabetic mice display a better recovery of AKI after experimental endotoxemia.
Moreover, these animals showed an increased expression of both HIF-1α and VEGF that was reproduced by incubating renal cells with GA.
Since VEGF is considered a survival factor for tubular cells, our findings suggest that diabetes displays HIF-1α upregulation that might function as a “precondition state” offering protection from endotoxic AKI.
American Psychological Association (APA)
Ortega, Arantxa& Fernández, A.& Arenas, María Isabel& López-Luna, P.& Muñóz-Moreno, C.& Arribas, Ignacio…[et al.]. 2013. Outcome of Acute Renal Injury in Diabetic Mice with Experimental Endotoxemia : Role of Hypoxia-Inducible Factor-1α. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-457766
Modern Language Association (MLA)
Ortega, Arantxa…[et al.]. Outcome of Acute Renal Injury in Diabetic Mice with Experimental Endotoxemia : Role of Hypoxia-Inducible Factor-1α. Journal of Diabetes Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-457766
American Medical Association (AMA)
Ortega, Arantxa& Fernández, A.& Arenas, María Isabel& López-Luna, P.& Muñóz-Moreno, C.& Arribas, Ignacio…[et al.]. Outcome of Acute Renal Injury in Diabetic Mice with Experimental Endotoxemia : Role of Hypoxia-Inducible Factor-1α. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-457766
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457766