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The Many Forms and Functions of Long Term Plasticity at GABAergic Synapses
Author
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
On February 12th 1973, Bliss and Lomo submitted their findings on activity-dependent plasticity of glutamatergic synapses.
After this groundbreaking discovery, long-term potentiation (LTP) and depression (LTD) gained center stage in the study of learning, memory, and experience-dependent refinement of neural circuits.
While LTP and LTD are extensively studied and their relevance to brain function is widely accepted, new experimental and theoretical work recently demonstrates that brain development and function relies on additional forms of plasticity, some of which occur at nonglutamatergic synapses.
The strength of GABAergic synapses is modulated by activity, and new functions for inhibitory synaptic plasticity are emerging.
Together with excitatory neurons, inhibitory neurons shape the excitability and dynamic range of neural circuits.
Thus, the understanding of inhibitory synaptic plasticity is crucial to fully comprehend the physiology of brain circuits.
Here, I will review recent findings about plasticity at GABAergic synapses and discuss how it may contribute to circuit function.
American Psychological Association (APA)
Maffei, Arianna. 2011. The Many Forms and Functions of Long Term Plasticity at GABAergic Synapses. Neural Plasticity،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-457786
Modern Language Association (MLA)
Maffei, Arianna. The Many Forms and Functions of Long Term Plasticity at GABAergic Synapses. Neural Plasticity No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-457786
American Medical Association (AMA)
Maffei, Arianna. The Many Forms and Functions of Long Term Plasticity at GABAergic Synapses. Neural Plasticity. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-457786
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457786