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Fatty Acids in Habitual Diet, Plasma Phospholipids, and Tumour and Normal Colonic Biopsies in Young Colorectal Cancer Patients
Joint Authors
Vatn, Morten H.
Berstad, Paula
Thiis-Evensen, Espen
Almendingen, Kari
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Fatty acid metabolism is altered in colorectal cancer (CRC).
We aimed to investigate incorporation of dietary n-6 and n-3 polyunsaturated fatty acids (PUFAs) into plasma phospholipids (PLs), tumour tissue, and normal mucosa in young CRC patients.
We also aimed to study differences in PUFA composition between tumour and normal mucosa, and PUFA status associated with cancer stage.
Sixty-five CRC patients younger than 55 years were included in a multicenter study.
We assessed dietary fatty acid composition by food-frequency questionnaire.
Fatty acid composition in plasma PL (n=65) and tumour and normal colonic biopsies (n=32) were analysed by gas chromatography.
We observed a significant correlation for docosahexaenoic acid (DHA) between dietary intake and concentration in plasma PL (weight%) (r=0.42; P=0.001), but not for any n-6 PUFA.
Tissue concentrations of arachidonic acid, eicosapentaenoic acid, and DHA (weight%) were 1.7–2.5 times higher in tumour than normal mucosa (P≤0.001).
Concentrations of n-3 and n-6 PUFA in plasma PL and tissues were not related to Duke's stage, although patients with more severe cancer stage reported higher intake of n-3 PUFA.
In conclusion, we found accumulation of the long-chained n-3 and n-6 PUFA in tumour tissue in young CRC patients.
American Psychological Association (APA)
Berstad, Paula& Thiis-Evensen, Espen& Vatn, Morten H.& Almendingen, Kari. 2012. Fatty Acids in Habitual Diet, Plasma Phospholipids, and Tumour and Normal Colonic Biopsies in Young Colorectal Cancer Patients. Journal of Oncology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-457797
Modern Language Association (MLA)
Berstad, Paula…[et al.]. Fatty Acids in Habitual Diet, Plasma Phospholipids, and Tumour and Normal Colonic Biopsies in Young Colorectal Cancer Patients. Journal of Oncology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-457797
American Medical Association (AMA)
Berstad, Paula& Thiis-Evensen, Espen& Vatn, Morten H.& Almendingen, Kari. Fatty Acids in Habitual Diet, Plasma Phospholipids, and Tumour and Normal Colonic Biopsies in Young Colorectal Cancer Patients. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-457797
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457797