Relationship between DNA Mismatch Repair Deficiency and Endometrial Cancer
Joint Authors
Ono, Asuka
Ueki, Arisa
Aoki, Daisuke
Kobayashi, Yusuke
Kisu, Iori
Yanokura, Megumi
Banno, Kouji
Hirasawa, Akira
Masuda, Kenta
Asahara, Nana
Susumu, Nobuyuki
Nomura, Hiroyuki
Source
Molecular Biology International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Some cases of endometrial cancer are associated with a familial tumor and are referred to as hereditary nonpolyposis colorectal cancer (HNPCC or Lynch syndrome).
Lynch syndrome is thought to be induced by germline mutation of the DNA mismatch repair (MMR) gene.
An aberration in the MMR gene prevents accurate repair of base mismatches produced during DNA replication.
This phenomenon can lead to an increased frequency of errors in target genes involved in carcinogenesis, resulting in cancerization of the cell.
On the other hand, aberrant DNA methylation is thought to play a key role in sporadic endometrial carcinogenesis.
Hypermethylation of unmethylated CpG islands in the promoter regions of cancer-related genes associated with DNA repair leads to the cell becoming cancerous.
Thus, both genetic and epigenetic changes are intricately involved in the process through which cells become cancerous.
In this review, we introduce the latest findings on the DNA mismatch repair pathway in endometrial cancer.
American Psychological Association (APA)
Masuda, Kenta& Banno, Kouji& Yanokura, Megumi& Kobayashi, Yusuke& Kisu, Iori& Ueki, Arisa…[et al.]. 2011. Relationship between DNA Mismatch Repair Deficiency and Endometrial Cancer. Molecular Biology International،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-457825
Modern Language Association (MLA)
Masuda, Kenta…[et al.]. Relationship between DNA Mismatch Repair Deficiency and Endometrial Cancer. Molecular Biology International No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-457825
American Medical Association (AMA)
Masuda, Kenta& Banno, Kouji& Yanokura, Megumi& Kobayashi, Yusuke& Kisu, Iori& Ueki, Arisa…[et al.]. Relationship between DNA Mismatch Repair Deficiency and Endometrial Cancer. Molecular Biology International. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-457825
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457825