Consequences of PPARα Invalidation on Glutathione Synthesis : Interactions with Dietary Fatty Acids
Joint Authors
Guelzim, Najoua
Martin, Pascal G.
Mathé, Véronique
Tomé, Daniel
Quignard-Boulangé, Annie
Huneau, Jean-François
Hermier, Dominique
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Glutathione (GSH) derives from cysteine and plays a key role in redox status.
GSH synthesis is determined mainly by cysteine availability and γ-glutamate cysteine ligase (γGCL) activity.
Because PPARα activation is known to control the metabolism of certain amino acids, GSH synthesis from cysteine and related metabolisms were explored in wild-type (WT) and PPARα-null (KO) mice, fed diets containing either saturated (COCO diet) or 18 : 3 n-3, LIN diet.
In mice fed the COCO diet, but not in those fed the LIN diet, PPARα deficiency enhanced hepatic GSH content and γGCL activity, superoxide dismutase 2 mRNA levels, and plasma uric acid concentration, suggesting an oxidative stress.
In addition, in WT mice, the LIN diet increased the hepatic GSH pool, without effect on γGCL activity, or change in target gene expression, which rules out a direct effect of PPARα.
This suggests that dietary 18 : 3 n-3 may regulate GSH metabolism and thus mitigate the deleterious effects of PPARα deficiency on redox status, without direct PPARα activation.
American Psychological Association (APA)
Guelzim, Najoua& Huneau, Jean-François& Mathé, Véronique& Quignard-Boulangé, Annie& Martin, Pascal G.& Tomé, Daniel…[et al.]. 2011. Consequences of PPARα Invalidation on Glutathione Synthesis : Interactions with Dietary Fatty Acids. PPAR Research،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-457841
Modern Language Association (MLA)
Guelzim, Najoua…[et al.]. Consequences of PPARα Invalidation on Glutathione Synthesis : Interactions with Dietary Fatty Acids. PPAR Research No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-457841
American Medical Association (AMA)
Guelzim, Najoua& Huneau, Jean-François& Mathé, Véronique& Quignard-Boulangé, Annie& Martin, Pascal G.& Tomé, Daniel…[et al.]. Consequences of PPARα Invalidation on Glutathione Synthesis : Interactions with Dietary Fatty Acids. PPAR Research. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-457841
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457841