Correlation between Oxidative Stress and Thyroid Function in Patients with Nephrotic Syndrome
Joint Authors
Sawant, Sangita U.
Almeida, Alan F.
Rajan, M. G. R.
Chandran, Subhash
Source
International Journal of Nephrology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-13
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
The present study is to look for a correlation between oxidative stress and thyroid function in patients with the nephrotic syndrome in the remission phase as well as in a persistent proteinuric state.
Introduction.
Nephrotic syndrome is a form of chronic kidney disease due to which blood loses protein through the urine.
We wanted to know if there was an increased loss of thyroid hormones in urine affecting thyroid function.
Methods.
60 patients with nephrotic syndrome and 20 healthy non-proteinuric individuals as control subjects were enrolled in the study.
We measured their serum tri-iodothyronine, thyroxine and thyroid-stimulating hormone.
Estimation of lipid peroxidation (LPx) catalase, superoxide dismutase (SOD), and Glutathione peroxidase (GPx) were carried out by standard methods.
Results.
TSH was elevated in the nephrotic patients compared to controls, while TT4 and TT3 were significantly lower in the patients than in controls.
Lipid Peroxidation and GPx were significantly higher in the nephrotic syndrome patients than in the controls, while SOD and catalase were significantly lower than in patients than in the control subjects.
Conclusion.
Nephrotic patients can lose significant amounts of thyroid hormones along with protein in urine, which can affect thyroid status, but this is reversible on remission.
American Psychological Association (APA)
Sawant, Sangita U.& Chandran, Subhash& Almeida, Alan F.& Rajan, M. G. R.. 2011. Correlation between Oxidative Stress and Thyroid Function in Patients with Nephrotic Syndrome. International Journal of Nephrology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-457867
Modern Language Association (MLA)
Sawant, Sangita U.…[et al.]. Correlation between Oxidative Stress and Thyroid Function in Patients with Nephrotic Syndrome. International Journal of Nephrology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-457867
American Medical Association (AMA)
Sawant, Sangita U.& Chandran, Subhash& Almeida, Alan F.& Rajan, M. G. R.. Correlation between Oxidative Stress and Thyroid Function in Patients with Nephrotic Syndrome. International Journal of Nephrology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-457867
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457867