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Potential Application of Tregitopes as Immunomodulating Agents in Multiple Sclerosis
Joint Authors
Elyaman, Wassim
Khoury, Samia J.
Scott, David W.
De Groot, Anne S.
Source
Neurology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The induction of immunologic tolerance is an important clinical goal in autoimmunity.
CD4+ regulatory T (Treg) cells, defined by the expression of the transcription factor forkhead box P3 (FoxP3), play a central role in the control of autoimmune responses.
Quantitative and qualitative defects of Tregs have been postulated to contribute to failed immune regulation in multiple sclerosis (MS) and other autoimmune diseases.
This paper highlights the potential uses of T regulatory cell epitopes (Tregitopes), natural Treg epitopes found to be contained in human immunoglobulins, as immunomodulating agents in MS.
Tregitopes expand Treg cells and induce “adaptive Tregs” resulting in immunosuppression and, therefore, are being considered as a potential therapy for autoimmune diseases.
We will compare Tregitopes versus intravenous immunoglobulin (IVIg) in the treatment of EAE with emphasis on the potential applications of Tregitope for the treatment of MS.
American Psychological Association (APA)
Elyaman, Wassim& Khoury, Samia J.& Scott, David W.& De Groot, Anne S.. 2011. Potential Application of Tregitopes as Immunomodulating Agents in Multiple Sclerosis. Neurology Research International،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-457869
Modern Language Association (MLA)
Elyaman, Wassim…[et al.]. Potential Application of Tregitopes as Immunomodulating Agents in Multiple Sclerosis. Neurology Research International No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-457869
American Medical Association (AMA)
Elyaman, Wassim& Khoury, Samia J.& Scott, David W.& De Groot, Anne S.. Potential Application of Tregitopes as Immunomodulating Agents in Multiple Sclerosis. Neurology Research International. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-457869
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457869