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Decreased PERP Expression on Peripheral Blood Mononuclear Cells from Patient with Rheumatoid Arthritis Negatively Correlates with Disease Activity
Joint Authors
Wang, Yantang
Du, Yanchun
Gan, Lu
Shi, Guixiu
Li, Yan
Deng, Lin
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
PERP, p53 apoptosis effector related to PMP-22, is a p53-dependent apoptosis in diverse cell types and has cell type-specific roles in p53-mediated apoptosis.
However, its role in PBMCs of RA patients has remained largely unclear.
Objectives.
The aim of this study was to detect the expression levels of PERP on PBMCs of RA patients and healthy controls and analyze the role of PERP in the pathogenesis of RA.
Methods.
The mRNA expression levels of PERP and IL-17 were detected by real-time PCR in PBMCs from patients with RA (n=40) and healthy controls (n=40).
The correlations of PERP expression levels to IL-17 transcripts and disease activity parameters were analyzed.
Results.
The PERP and IL-17 expression levels in the PBMCs were significantly decreased and increased in comparison of which in healthy controls.
The mRNA expression levels of PERP in PBMCs from patients with RA were negatively correlated with IL-17 and disease activity parameters DAS28, RF, CRP, and ESR rather than Anti-CCP and ANA.
Conclusions.
These results demonstrated that PERP might be involved in the pathogenesis and a potential therapeutic target of RA by regulating the expression of IL-17.
American Psychological Association (APA)
Du, Yanchun& Deng, Lin& Li, Yan& Gan, Lu& Wang, Yantang& Shi, Guixiu. 2013. Decreased PERP Expression on Peripheral Blood Mononuclear Cells from Patient with Rheumatoid Arthritis Negatively Correlates with Disease Activity. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-457870
Modern Language Association (MLA)
Du, Yanchun…[et al.]. Decreased PERP Expression on Peripheral Blood Mononuclear Cells from Patient with Rheumatoid Arthritis Negatively Correlates with Disease Activity. Clinical and Developmental Immunology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-457870
American Medical Association (AMA)
Du, Yanchun& Deng, Lin& Li, Yan& Gan, Lu& Wang, Yantang& Shi, Guixiu. Decreased PERP Expression on Peripheral Blood Mononuclear Cells from Patient with Rheumatoid Arthritis Negatively Correlates with Disease Activity. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-457870
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457870