The Transmission DisequilibriumHeterogeneity Test with Parental-Genotype Reconstruction for Refined Genetic Mapping of Complex Diseases
Joint Authors
Source
Journal of Probability and Statistics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-05
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
In linkage analysis for mapping genetic diseases, the transmission/disequilibrium test (TDT) uses the linkage disequilibrium (LD) between some marker and trait loci for precise genetic mapping while avoiding confounding due to population stratification.
The sib-TDT (S-TDT) and combined-TDT (C-TDT) proposed by Spielman and Ewens can combine data from families with and without parental marker genotypes (PMGs).
For some families with missing PMG, the reconstruction-combined TDT (RC-TDT) proposed by Knapp may be used to reconstruct missing parental genotypes from the genotypes of their offspring to increase power and to correct for potential bias.
In this paper, we propose a further extension of the RC-TDT, called the reconstruction-combined transmission disequilibrium/heterogeneity (RC-TDH) test, to take into account the identical-by-descent (IBD) sharing information in addition to the LD information.
It can effectively utilize families with missing or incomplete parental genetic marker information.
An application of this proposed method to Genetic Analysis Workshop 14 (GAW14) data sets and extensive simulation studies suggest that this approach may further increase statistical power which is particularly valuable when LD is unknown and/or when some or all PMGs are not available.
American Psychological Association (APA)
Han, Jing& Shao, Yongzhao. 2012. The Transmission DisequilibriumHeterogeneity Test with Parental-Genotype Reconstruction for Refined Genetic Mapping of Complex Diseases. Journal of Probability and Statistics،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-457879
Modern Language Association (MLA)
Han, Jing& Shao, Yongzhao. The Transmission DisequilibriumHeterogeneity Test with Parental-Genotype Reconstruction for Refined Genetic Mapping of Complex Diseases. Journal of Probability and Statistics No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-457879
American Medical Association (AMA)
Han, Jing& Shao, Yongzhao. The Transmission DisequilibriumHeterogeneity Test with Parental-Genotype Reconstruction for Refined Genetic Mapping of Complex Diseases. Journal of Probability and Statistics. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-457879
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457879