PPARγ as a Potential Target to Treat Airway Mucus Hypersecretion in Chronic Airway Inflammatory Diseases
Joint Authors
Wen, Fuqiang
Shen, Yongchun
Chen, Lei
Wang, Tao
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Airway mucus hypersecretion (AMH) is a key pathophysiological feature of chronic airway inflammatory diseases such as bronchial asthma, cystic fibrosis, and chronic obstructive pulmonary disease.
AMH contributes to the pathogenesis of chronic airway inflammatory diseases, and it is associated with reduced lung function and high rates of hospitalization and mortality.
It has been suggested that AMH should be a target in the treatment of chronic airway inflammatory diseases.
Recent evidence suggests that a key regulator of airway inflammation, hyperresponsiveness, and remodeling is peroxisome proliferator-activated receptor gamma (PPARγ), a ligand-activated transcription factor that regulates adipocyte differentiation and lipid metabolism.
PPARγ is expressed in structural, immune, and inflammatory cells in the lung.
PPARγ is involved in mucin production, and PPARγ agonists can inhibit mucin synthesis both in vitro and in vivo.
These findings suggest that PPARγ is a novel target in the treatment of AMH and that further work on this transcription factor may lead to new therapies for chronic airway inflammatory diseases.
American Psychological Association (APA)
Shen, Yongchun& Chen, Lei& Wang, Tao& Wen, Fuqiang. 2012. PPARγ as a Potential Target to Treat Airway Mucus Hypersecretion in Chronic Airway Inflammatory Diseases. PPAR Research،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-457904
Modern Language Association (MLA)
Shen, Yongchun…[et al.]. PPARγ as a Potential Target to Treat Airway Mucus Hypersecretion in Chronic Airway Inflammatory Diseases. PPAR Research No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-457904
American Medical Association (AMA)
Shen, Yongchun& Chen, Lei& Wang, Tao& Wen, Fuqiang. PPARγ as a Potential Target to Treat Airway Mucus Hypersecretion in Chronic Airway Inflammatory Diseases. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-457904
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457904