Epigenetic Alterations in Muscular Disorders
Author
Source
Comparative and Functional Genomics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Epigenetic mechanisms, acting via chromatin organization, fix in time and space different transcriptional programs and contribute to the quality, stability, and heritability of cell-specific transcription programs.
In the last years, great advances have been made in our understanding of mechanisms by which this occurs in normal subjects.
However, only a small part of the complete picture has been revealed.
Abnormal gene expression patterns are often implicated in the development of different diseases, and thus epigenetic studies from patients promise to fill an important lack of knowledge, deciphering aberrant molecular mechanisms at the basis of pathogenesis and diseases progression.
The identification of epigenetic modifications that could be used as targets for therapeutic interventions could be particularly timely in the light of pharmacologically reversion of pathological perturbations, avoiding changes in DNA sequences.
Here I discuss the available information on epigenetic mechanisms that, altered in neuromuscular disorders, could contribute to the progression of the disease.
American Psychological Association (APA)
Lanzuolo, Chiara. 2012. Epigenetic Alterations in Muscular Disorders. Comparative and Functional Genomics،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-457907
Modern Language Association (MLA)
Lanzuolo, Chiara. Epigenetic Alterations in Muscular Disorders. Comparative and Functional Genomics No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-457907
American Medical Association (AMA)
Lanzuolo, Chiara. Epigenetic Alterations in Muscular Disorders. Comparative and Functional Genomics. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-457907
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457907